Recently, in a research report published in the international magazine ACS Nano, researchers from the Hong Kong Polytechnic University of China have developed a new type of nanobiosensor for rapid detection of influenza and other viruses. The new biosensor utilizes an optical method called up-conversion luminescence resonance energy transfer (LRET) for ultra-sensitive virus detection.
The researchers say the new optical method is very simple and can reduce the test time from 1-3 days to 2-3 hours today, which is 10 times faster than traditional clinical methods, and each sample It only costs 20 Hong Kong dollars, which is 80% lower than the traditional testing cost; therefore, this new technology can be widely used to detect different kinds of viruses, providing a low-cost, fast and ultra-sensitive virus detection technology for later development. New ideas.
Traditional methods for detection of influenza viruses include genetic analysis, which uses RT-PCR and ELISA methods; however, ELISA methods are relatively less sensitive, while RT-PCR methods are more sensitive but expensive, such as limitations making these techniques difficult In the first line or as an on-site diagnostic tool for virus detection, the researchers have developed a new type of upconversion nanobiosensor that can detect viruses using luminescence technology.
The biosensor developed by the researchers is based on luminescence technology, just like two magnets that can attract each other, mainly by upconversion nanoparticles (UCNPs) coupled with a probe oligonucleotide, in the probe. The DNA constructor pairs each other with influenza virus oligonucleotides in gold nanoparticles. In the beginning, scientists used the up-conversion luminescence resonance energy transfer process to detect the virus in the liquid phase system. In this study, the researchers used a solid-phase nanoporous membrane system (NAAO) to treat the virus. Perform highly sensitive luminescence detection.
In contrast to traditional clinical methods, researchers have developed this device very simply, without the need for expensive equipment and complex operating techniques, while the new biosensors have less damage to genetic material and do not induce background fluorescence. In addition, because each virus has a unique genetic sequence, researchers can design a complementary probe; in other words, this LRET technique can be widely used in many different ways by modifying the capture probes of UCNPs. Detection of the virus.
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