Application of traditional Chinese medicine compound FAHF-2 in the treatment of inflammatory bowel disease

On May 2nd, the 20th Future Health Technology Summit was held at the Massachusetts Institute of Technology. Dr. Li Xiumin, a Chinese professor at Mount Sinai School of Medicine, was awarded the “2016 Future Health Technology Award” in recognition of her use of Chinese herbal medicine for the treatment of allergies and immune system diseases. Outstanding contributions made by the parties. The article shared today for everyone is one of Professor Li's research.

Anti-inflammatory Effects of the Chinese Herbal Formula FAHF-2 in Experimental and Human IBD. 2014. Inflamm Bowel Dis. (IF: 4.358)

The drug is the traditional Chinese medicine compound FAHF-2. Using this as a keyword to pubmed, there have been more than 20 articles. There have been reports of clinical phase I in 2010 and 2011. It is an old medicine.

Figure 1. In an in vitro cell model (RAW264.7), FAHF-2 inhibits inflammatory factor secretion (TNF-a) stimulated by LPS. There is a concentration gradient effect.

Figure 2, animal modeling, dosing to see the effect of treatment.

E is the secretion of inflammatory factors.

Figure 3, human experiment. Because there are clinical experiments in front, there are samples of some people.

The ABC maps are all human-derived PBMC cell data.

Figure 4. TNF-a is secreted by CD14 monocytes and CD3 T cells. Here, it was found that FAHF-2 can reduce both types of cells.

Figure 5, human experiment. However, instead of using monocytes, biopsy samples are cultured to detect inflammatory factor secretion.

Figure 6. Looking for molecular mechanisms, it is believed that FAHF-2 inhibits inflammation through IKBa.

to sum up

1. Take the conclusion on the cell line and then verify it on the primary cultured cells. Everyone must remember this idea.

2. The detection index uses a molecular marker.

3. The full text is basically to explore the effectiveness of drugs in cell models and animal models, the molecular mechanism is very simple. The reason is that this compound has not been done in the cytological anti-inflammatory function, and it is a new drug from this perspective. To be effective, new drugs need to be repeatedly proven in cells and animals, and the molecular mechanism plus classical molecular detection (old genes) is more convincing. This drug, the latter research work needs to be deeply explored in the molecular mechanism to find innovation.

PS: I hope that friends who have more exchanges with Jibo in learning and experimentation can pay attention to Jikai Gene WeChat and reply to the words “Jibo”.

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