Obesity has become a global health issue, and a large body of evidence suggests that obese people have a higher risk of colon cancer, and colon tissue inflammation is a major risk factor for colon cancer. A study published in the Journal of the National Academy of Sciences on the 30th revealed a new molecular mechanism of obesity that increases colon tissue inflammation.
Laboratory study of the soluble epoxide hydrolase (sEH) and obesity-induced inflammation of colon tissue in mouse experiments by the Zhang Guodong Laboratory at the University of Massachusetts Amherst and the University of California at Davis Bruce Hammock Laboratory Related, inhibition of this enzyme can control the inflammation of the colon tissue, thereby reducing the risk of colon cancer.
Using metabolomics methods based on liquid chromatography-mass spectrometry, the researchers found that the sEH produced by the sEH in the obese mice group contained higher levels of fatty acid metabolites. The author of the paper, Zhang Guodong, said: “Based on metabolomics data, we further found that the expression of sEH in the colon of obese mice was significantly higher.â€
The researchers used two different enzyme inhibitors and mouse tests that did not produce this enzyme after knockout, confirming that sEH plays a key role in obesity-induced colon inflammation.
"After sEH was knocked out, even obese mice fed a high-fat diet had inflammation in the colon tissue, indicating that sEH inhibitors may be an effective means to prevent obesity-induced colon cancer and rectal cancer." Zhang Jianan, a doctoral student, said.
Currently, sEH inhibitors have entered human clinical trials for the treatment of other inflammatory diseases. Phase 1 human clinical trials have found that these drugs are safe and have no side effects. Zhang Guodong said that these clinical resources will promote the future use of these drugs to prevent the risk of colon cancer and rectal cancer caused by obesity without having to develop drugs from scratch.
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