The British journal Nature recently published two genetic papers. The European team reported the genomes of mexican and worms, respectively, revealing the genetic basis behind the mysterious “regeneration capacityâ€. Among them, the 32 billion base pairs of mexiletine are the largest genomes currently assembled.
All of the limbs of the mexican can be regenerated, and the true worm can even grow out of the body after being cut into pieces. Researchers have always wanted to thoroughly understand the mysteries of this, and to understand the underlying genetic mechanism behind the "regeneration capacity" that humans do not have.
This time, the team of scientists at the Austrian Institute of Molecular Pathology sequenced the genome of the American West, which contains 32 billion base pairs, 10 times the human genome, and is the largest genome currently assembled. The researchers labeled those genes and miRNA sequences that are abundantly expressed in regenerative limb cells for further research, and found that mexiletine lacks the Pax3 gene, a gene that is critical for the development of many other animals.
The team at the Institute of Molecular Cell Biology and Genetics at the Max Planck Institute in Germany sequenced the genome of the true planarian, which contains about 800 million base pairs. The genome of the true planarian lacks approximately 124 genes that are critical for humans and mice, including genes involved in DNA repair and genes that help chromosomes properly separate during cell division.
The genomes of both mestre and worms contain high levels of repetitive DNA sequences, making them difficult to analyze. Scientists have adopted a new computational method combined with long-length sequencing to improve genome assembly. It is now known that some of its repetitive sequences are involved in embryonic development and stem cell activity. Whether they are the key to the miraculous ability of mexican and true worms is the focus of the researchers' next research.
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The genome is the Moss code of nature. Once it is deciphered, many life secrets can be learned. Not long ago, domestic scholars found on the basis of gene sequencing that the valuable Chinese herbal medicine Cordyceps sinensis does not contain cordycepin, which is a conclusion for the debate about whether Cordyceps sinensis contains cordycepin. Compared with common Cordyceps, the number of base pairs in the Cordyceps genome is very large, contains a large number of repetitive gene fragments, and the role of most genes is still unknown. How is this similar to the situation of mexican and worms? ! This shows that many Morse codes of complex life phenomena in nature still need to be further deciphered. (People's Network)
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