Capillaris heat and dampness; yellowing. Indications: jaundice, adverse urination, itchy itch, infectious jaundice hepatitis. Etc. Pharmacological studies are beneficial for gallbladder, protecting liver function, antipyretic, anti-inflammatory, hypolipidemic, antihypertensive, and crown-expanding effects.
1. Yinchen treatment patient is golden, not many languages, limb weakness, good sleep lying, spit mucus: 50 grams of Artemisia capillaris, white peony root. The two flavor rough sieve. Each serving 15 grams, a water simmer, fry six minutes, go to simmer, warm clothes before eating, Japan. ("The Story of Sheng Ji" Yin Chentang)
2, Yin Chenzhi men's wine ç–¸: Artemisia wormwood four, wolfberry seven, a large field snail, and even smashed shell, a hundred bottles of white wine, a large bowl of wolfberry juice drink it. ("Outline")
3, Yinchen cure Yangming disease, but the head sweating, body without sweat, neck and still, urine negative, thirsty cited water slurry, hot in the body, body hair yellow. Artemisia wormwood sixty-two, fourteen scorpions (擘), rhubarb two (tare). Two liters of water and one bucket, first boiled capillaris, six liters less, two flavors inside, boiled three liters, and served three servings. Urinating when urine, such as saponin sauce. ("Treatise on the Cold" Zhang Zhongjing Yin Chenhao Tang)[2]
4, Yinchen governance yellow, late pulse, body cold, waist above self-sweat: capillaris 100 grams, aconite one for eight, dried ginger (gun) 75 grams. Licorice (ç‚™) one or two. The rough end. Divided into four stickers, Shuijianbi. ("Jade Machine Micro-Yi" Yin Chen Sini Soup)
5, capillaris cure colds, jaundice, paint sores: capillaris five money. Shuijianbi. ("Hunan Drug Journal")
6, Yinchen cure stubble wind disease (the disease is the body patches, white into pieces): Artemisia and Artemisia two grip, water and a bucket of five liters, boiled seven liters, the first to wash soap soup, the soup washed this time Colder, more clean, wash every other day, otherwise, fear of pain. ("Cui's Reigns")
7, all over the code: A hand with Artemisia annua, a piece of smashed ginger, daily rubbed chest and limbs.
8. Inflammation of the eyes: Use Artemisia capillaris, psyllium, etc., decoction, transfer several times with fine tea.
9, hot yellow soup: with capillaris cut soup soup. Raw food can also be used to treat typhoid, headache, hot wind, itchiness and urination. This name is Yin Chen.
10, wind disease urgency (by: refers to the hands and feet can not be freely retracted): with Artemisia annua one pound, glutinous rice and a stone, face three pounds, and uniform as usual wine, daily Beverage Service.
11, capillaris cure all the wind itching raw acne: capillaris countless, boiled juice washed. ("Qian Jinfang")
12, capillaris cure wind phlegm addiction, skin itching: Yin Chen Artemisia 50 grams, lotus leaf 25 grams. On the two flavors are scattered. 5 grams per serving, adjusted with cold honey, served after eating. ("Sheng Ji Zonglu" Yin Chenhao San)
Pharmacological effects
Heat and dampness; yellowing. Indications: jaundice, adverse urination, itchy itch, infectious jaundice hepatitis and other pharmacological studies favor gallbladder, protection of liver function, antipyretic, anti-inflammatory, hypolipidemic, such as the role of crown expansion, of course, this is only Western medicine extract capillaris ingredients Out of the study, the clinical application of the effect is not good enough to determine. Chen Su's toxicity is central inhibition, manifested as sleepiness, rogue and so on. Excessive use of capillaris can cause dizziness, nausea, diarrhea, upper abdominal discomfort, acute liver and gallbladder injury, and reports of irregular heartbeats, but therapeutic doses of capillaris do not generally cause severe damage.
Capillaris has a significant hepatoprotective effect and has significant effects on hepatitis A, B, and jaundice hepatitis. Advantageous gallbladder, promote bile secretion, increase bile acid and bilirubin excretion, increase coronary blood flow in the heart, improve microcirculation, and lower blood pressure, blood fat, anticoagulant, diuretic antipyretic asthma, Repels aphids and inhibits a variety of pathogenic dermatophytes and bacteria.
1, the role of gallbladder:
This product is decoction, flooding, detersive oil
Infusions, volatile oils, alcohol extracts, 6,7-dimethoxycoumarin, chlorogenic acid, etc. all promote bile secretion and choleretic effect. This product is flooded with 0.25g/kg, or refined infusion (removed and not removed volatile oil) 1g/kg intravenously in acute gallbladder intubation dogs, or 1g/kg refined infusion to chronic gallbladder stoma dogs gavage, Regardless of the liver damage caused by healthy or carbon tetrachloride, gallbladder effect is beneficial, and the dry weight of bile secretion increases. 6,7-dimethoxycoumarin 0.2 g/kg or 0.3 g/kg was injected into the duodenum of anesthetized rats, and bile secretion was increased by an average of 50% or 180% after 30 minutes. Chronic gallbladder stoma dogs were intragastrically administered 0.3 g/kg, and the bile averaged 73.86% within 3 hours. Capricorne is also the main choleretic ingredient that promotes bile excretion. p-Hydroxyacetophenone has a marked choleretic effect on rats and can increase bile secretion. It also increases the output of bile solids, bile acids, and bilirubin. It also has the same effect on carbon tetrachloride-induced liver damage. effect. It was also reported that the strength of the gall bladder effect of the capillaris component was in order of caprylic coumaric acid A, capillarin coumaric acid B, 6,7-dimethoxycoumarin, and artichoke chromone.
Injection
0mg/kg capsular ketoketone, intravenous injection of lOOmg/kg capsular keratin ketone in rats have obvious choleretic effect, while 6,7-dimethoxycoumarin is not obvious, capillaris decoction can also Decreased anesthetic dog sphincter tone. Capillara diacetyl, capreolone and caproside also promote the secretion and excretion of bile.
2, the impact on the liver:
For rats with hepatic impairment caused by carbon tetrachloride, 0.61 g of Yinchen decoction was injected subcutaneously every day. On the 8th day, histological examination was performed. It was seen that hepatocyte swelling, ballooning, steatosis, and necrosis in the treatment group were all higher than those in the control group. The groups have different degrees of relief.
Oral liquid
The original and ribonucleic acid content was restored or nearly normal, serum alanine aminotransferase activity was significantly decreased, indicating that there is still a certain hepatoprotective effect, Artemisia capillaris water decoction 0.25ml/10g gavage to mice, 2 times a day For 4 consecutive days, liver P450 content was measured. The results showed that Yinchen decoction can increase the content of hepatic P450 in mice, increase the ratio of liver/body weight, shorten the sleep time induced by isome pentobarbital, and initially showed that Yinchen decoction induces liver enzymes in mice. effect. As liver enzymes are involved in the metabolism of drugs, they are also involved in the metabolism of bile acids, bilirubin, esters and certain toxicants. The induction of liver enzymes may be related to the functions of capillaris, gallbladder, and yellowing.
The effects of some flavonoids and coumarins in Capillaris meyenii on the hepatocellular cytotoxicity induced by CCl4 or galactose in rats were in the order of capillaris chromone, scoparin, and 6,7-dimethoxy benzoate. Soybean, capillaris, quercetin, isorhamnetin. The active ingredients in Yinchenhao Decoction can significantly reduce the serum glutamate-pyruvic transaminase (SGPT) and aspartate aminotransferase (SGOT) levels in acute jaundice rats, and the effect on serum bilirubin (SB) is slight. In addition, 6,7-dimethoxycoumarin has a strong inhibitory effect on hepatocyte damage.
3, antipyretic effect:
Effects on normal body temperature in mice: mice were intraperitoneally injected with Boswellia officinalis water suspension 40, 80 mg/kg, and control was normal saline. The normal body temperature before administration of each group was 37.7±0.06, 37.8±0.07 and 37.7±0.08°C (X±SE), and body temperature was measured 30 minutes after administration, and the mean values ​​were 36.3±0.05, 35.5±0.04 and 37.6±, respectively. 0.08°C. The body temperature of the administration group was lower than that before administration, and the difference was very significant (P<0.01). There was no change in the control group. Another 40,20mg/kg dose, intraperitoneal injection of two groups of mice, continuous determination of body temperature, 40mg/kg dose group continued to cool up to 6 hours, 20mg/kg group body temperature gradually restored around 3 hours.
Effects on normal body temperature in rats: Rats weighing 40-60 g were given oral or intraperitoneal injections of heroin, divided into five dose groups (125, 250, 500 mg/kg, and 5, 20, 40 mg/kg). , Chlorpromazine positive control and normal control group. The rectal temperature was measured at 0.5, 1, 2, 3, 4, and 8 hours after administration. Results The normal body temperature of the rats in the administration group was significantly decreased. The intensity of the effect was positively related to the dose. The temperature decreasing amplitude increased with the increase of the dose, and the action time prolonged with the increase of the dose. Generally, the body temperature drops about 0.5 hours after administration, peaks at 1-2 hours, and maintains for about 4 hours.
Antipyretic effects on rats induced by fresh beer yeast: Oral mycotoxin (1% shixi gum suspension) 250 mg/kg and oral compound analgin (aminopyrine 400 mg/kg, dipyrone 600 mg/kg) An oral equivalent volume of 1% tragacanth gum was used as a control. Results The results showed that the effect of heroin and compound Analgin on fever induced by fresh beer yeast was mild. The fever was relieved 0.5 hours after administration, and the body temperature was reduced by about 3°C ​​in about 2 hours. About 4 hours.
Antipyretic and prophylactic effects of 2,4-dinitrophenol-induced rats: Intraperitoneal injection of heroin 40 mg/kg compared with the positive control aminopyrine 80 mg/kg and saline control group, drug administration group for 3 hours The rate of body temperature decline was significantly different from that of the normal saline control group (P<0.05), and the prophylactic effect of heroin was higher than that of aminopyrine (P<0.05).
Intraperitoneal injection of capillaranin at 20 mg/kg has a good antipyretic effect on rabbits caused by expired Salmonella typhi and 2,4-dinitrophenol.
4. Hypolipidemic effect, expansion of coronary artery and fibrinolysis: 3 g/kg of capillariae was given to experimental hypercholesterolemic rabbits. After treatment for 2-3 weeks, the serum cholesterol in the treatment group decreased by 19.2 mg% and 30 mg, respectively. The percentage of β-lipoprotein was also decreased significantly. Arterial wall atherosclerosis was lighter than that of the control group. The cholesterol content of rabbit aortic wall was also significantly lower than that of the control group, indicating that capillaria baicalensis has a certain anti-atherosclerotic effect. Both capillaris injection and 6,7-dimethoxycoumarin can increase the coronary flow of isolated rabbit hearts. Calcium in the summer time, antithrombin effect observation, protein electrophoresis, fibrinolysis test, grape amylin aggregation test, fibrin (raw) lysate product test proved that the bacteria Chen anticoagulant and promote fibrinolysis. 6,7-Dimethoxycoumarin inhibits the contractile action of NE, 5-HT, HIS and At-II on vascular smooth muscle, and its mode of action is similar to that of nitroglycerin.
5, lower blood pressure effect:
Yinchen extract, ethanol, aqueous extract, volatile oil and 6,7-dimethoxycoumarin all have hypotensive effect. The latter 0.4-10mg/kg intravenous or duodenal administration, have significant blood pressure lowering effect on general anesthesia or local anesthesia rats, cats and rabbits. This effect is not blocked by hexahydrocarbyl quaternary amines and atropine. It is not enhanced by benzylaminozoline and does not act against the elevating effect of epinephrine. When a 1/50-1/10 intravenous dose was injected into the vertebral artery, the blood pressure reducing intensity was approximately equal to the whole amount, suggesting that the blood pressure lowering effect may be central. 6,7-Dimethoxycoumarin enhances the contractile force of rabbit hearts and cat hearts. There is significant hypotensive and tranquilizing effect of scoparone lactone. The antihypertensive effect was stronger than that of methyldopa. Intravenous injection of lOmg/kg in canine decreased the blood pressure by 58.6% and lasted for 160 minutes. At the same dose, the blood pressure of methyldopa decreased by 12.4% and lasted for 120 minutes. The scoparone lactone also has a diuretic effect.
6, antibacterial, anti-inflammatory effects:
In vitro tests showed that Yinchen decoction against Staphylococcus aureus, diphtheria bacillus, Bacillus anthracis, Salmonella typhi, Salmonella paratyphi A, Pseudomonas aeruginosa, Escherichia coli, Shigella flexneri, Shigella dysenteriae, meningitis double Cocci, Bacillus subtilis, etc. have different degrees of inhibition. 10% decoction can completely inhibit the growth of human Mycobacterium tuberculosis. A concentration of 1:100 inhibited both human and bovine tuberculosis. The in vitro test of capillaris chromogens has an antagonistic effect on the antibacterial action of chloramphenicol. Capillara diacetylenic ketone has a high antibacterial effect, especially a strong effect on the dermatophyte filamentous fungus, showing a bactericidal effect. After a long time of high temperature treatment above 100 °C, its antibacterial power is still not reduced. In the concentration of 0.25μg/ml can also completely prevent the growth and reproduction of Scarlet wool. The scoparone lactone has anti-inflammatory effects on rat edema caused by carrageenan. Both acetic acid writhing and hot plate methods showed analgesic effects.
7, the role of smooth muscle:
Yinchen decoction and alcohol infusion have slightly excitatory effect on isolated rabbit intestine. The water infusion can inhibit the dog in situ and rabbit intestinal muscle activity. Volatile oil can reduce the activity and tension of isolated frogs and rabbits. The purified extract had excitatory effects on ex vivo uteri of rabbits and guinea pigs. The stimulatory effect on non-pregnant guinea pig uterus can be antagonized by diphenhydramine.
8, the impact of aflatoxin:
Inhibition of TA98 and TA100 base substitution mutations induced by the carcinogen Aflatoxin B1 (AFB1) in the decoction of Artemisia annua water decoction indicates that the decoction of Amorphophallus artemisia has significant inhibition on the mutagenicity of AFB1 The effect is dose-effect relationship. The tips may be of interest for preventing liver cancer.
9, the role of immune function:
Artemisia capillaris promotes the division of white blood cells, increases the number of leukocytes, increases the immune activity of T cells, participates in the immune regulation of the body and induces the effects of interferon, etc., thereby enhancing the immune function of the body in many ways. Caffeine in capillaris has the effects of increasing the number of white blood cells, stopping gallbladder bleeding, and resisting fertility. Oral capillaries 250 mg/kg could significantly enhance delayed-type hypersensitivity in transplanted tumor mice.
10, other roles:
The product and its components also have the effects of anti-Leptospira, acarid, antiasthmatic, anti-asthmatic mouse Ehrlich ascites carcinoma cells and MethA cells.
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