Antibacterial toothpaste does not affect intestinal flora and oral microbes

Release date: 2016-05-24

According to small randomized trials, some personal hygiene products containing antibiotics such as triclosan, such as soap and toothpaste, have no significant effect on microbial community or endocrine function. The results of this study were published online on mSphere.

“Many people are afraid of triclosan, but we have not found any relevant support arguments in our research,” said Dr. Julie Parsonnet, MD. “When most antibiotics are applied to humans, these antibiotics are atomic bombs in the microbiota. But we found that when people came into contact with triclosan through normal household products, it did not have a major impact on our microbial ecosystem."

In recent years, changes in the composition of the human microbiome have been linked to diseases such as diabetes, metabolic syndrome and obesity. Triclosan, first licensed in the early 1960s, is now widely used in household cleaning and personal care products. The use of triclosan is so common that the presence of triclosan was found in 75% of human urine samples as early as 2008.

In recent years, researchers have been concerned that the widespread use of triclosan can lead to antibiotic resistance or adverse effects on human microbial flora. In 2013, the US Food and Drug Administration issued a rule requiring manufacturers of antimicrobial soaps and body washes to provide evidence within one year that the product containing triclosan is safe and more versatile than ordinary soap. Effective prevention of disease. Market feedback said that triclosan has been largely removed from commercial soaps in the United States, but it still exists in some hospital cleaning products in the United States and the most common toothpastes such as Colgate. Triclosan reduces plaque burden and gingivitis.

In a new double-blind, randomized, crossover study, Stanford University researchers randomly selected 13 healthy individuals to continue using household and personal care products (toothpaste, hand sanitizer, detergent) for four months, some of which contained three Chlorine, some do not contain triclosan. After four months, they used other alternatives. The researchers analyzed the metabolic and endocrine markers of blood samples, the triclosan of urine samples, the microbial flora of feces and oral samples.

Products containing triclosan have a significant effect on the triclosan content in the urine, but have no significant effect on oral or intestinal microbes or metabolic markers. “We found that some microbes changed a bit, but the oral or gut microbiota did not change much,” Dr. Parsonnet said. “For those who are very afraid of triclosan, this research should be reassuring.”

Source: Bio Valley

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