The National Cancer Center relies on the Cancer Hospital of the Chinese Academy of Medical Sciences. It is the center of national cancer prevention research and information exchange. It undertakes the responsibility of collecting and publishing national cancer registration data, establishing a national cancer prevention and collaboration network, and carrying out national cancer prevention and control scientific research. The implementation of the early diagnosis and treatment of cancer in urban, rural, and Huaihe River basins and the work of high-spot discovery sites are also the national cancer standardization diagnosis and treatment quality control center, the National Cancer Clinical Medical Research Center, etc., which is the collection, analysis, research, and reporting of national cancer clinical big data. The center of the release. In the process of participating in the clinical macrodata related research project undertaken by the National Cancer Center/Chinese Academy of Medical Sciences Cancer Hospital, some difficulties and problems have been encountered repeatedly. Some experience and experience have been obtained during the process, and thus the future There is a deeper understanding of the key and difficult points of tumor big data research.
National Cancer Center/Chinese Academy of Medical Sciences Peking Union Medical College Cancer Hospital Thoracic Surgery Gao Yibo
Tumor clinical big data series research layout
The Department of Thoracic Surgery of the Cancer Hospital of the Medical Academy has been in the "Tenth Five-Year Plan" and "Eleventh Five-Year Plan" period, that is, relying on the China Association of Anticancer Association's Esophageal Cancer Professional Committee to lead the construction of a standardized online diagnosis and treatment network platform for esophageal cancer. As the earliest established large-scale intelligent information network platform for tumor specific diseases in China, there are 82 large-scale and high-level tertiary hospitals in the clinical diagnosis and treatment of esophageal cancer, and 12 regional-level sub-centers have been set up. It covers all provincial administrative units except Taiwan and Tibet. It adopts standardized data standards and network direct reporting platform, and has accumulated 32,600 cases of surgical and comprehensive treatment of esophageal cancer. It is a national diagnosis and treatment technology and model for esophageal cancer. Standardization has made a unique contribution. As an important part of the research and application of the key technologies for the standardized diagnosis and treatment of esophageal cancer, it won the first prize of the 2013 National Science and Technology Progress Award.
During the 12th Five-Year Plan period, based on the previous successful experience in the construction and research of clinical big data network for esophageal cancer, the National Cancer Center/Tumor Hospital undertook the National Science and Technology Support Program project “Research on the Diagnosis and Treatment of Tumors Based on Cancer Surveillance Information Network†and the National High The technical development (863) program "heavy tumor big data processing analysis and applied research" task, targeting China's eight major tumors with high morbidity, mortality and social burden: lung cancer, liver cancer, esophageal cancer, stomach cancer, colon cancer, rectum Cancer, breast cancer, cervical cancer, networked Northeast, North China, Central China, East China, South China, Southwest, Northwest, and seven provincial-level cancer hospitals/cancer centers with representative and regional demonstrations Key technology research on acquisition, storage, processing and analysis, construction of tumor big data center and system platform; application of big data technology to process and analyze massive clinical data generated during tumor treatment, and form data with tumor single disease as the theme Set up a knowledge base and analysis model library for the diagnosis and treatment of tumor diseases Decision support; to carry out standardization of diagnosis and treatment of cancer research, establish a quality control system to optimize cancer prevention and control strategies, improve the comprehensive diagnosis and treatment of cancer and so on.
Main contents and progress of clinical macrodata series of cancer
The specific content of current tumor big data research can be summarized as follows: 1 Determine the content and specifications of the collected data: including basic information of patient demographics, morbidity and diagnosis information, treatment information, follow-up information, scientific research information, etc.; National Cancer Surveillance Network: build network infrastructure, data exchange, data center, business application, integrated management, etc.; 3 build a single disease database: identify the database fields of each specialty, automatically import structured fields into the system, and use data mining tools Unstructured data is included; 4 comprehensive data analysis: scheduled report model to deeply analyze tumor classification, diagnosis and treatment, cancer death analysis, cancer control statistical analysis, treatment costs, etc.; 5 data reporting quality control: design information system standard data interface, Standardize the data dictionary; collect the interface data of each hospital, verify the reported data, check the integrity, type integrity, data item integrity, etc.; data cleaning, processing problem data, collecting original data, ensuring data traceability; organizing medical professional Personnel industry Logic verification and data correction, and complement and improve the data dictionary and collection specifications; 6 standardization diagnosis and treatment of cancer: formulate or update the cancer diagnosis and treatment standards suitable for China's national conditions, modify and improve the cancer staging standards that meet the characteristics of Chinese patients, and obtain compliance High-level evidence from the medical science is used to guide the clinic.
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