At the end of last year, a study published by Nature, a research team led by MIT neuroscientist Li-Huei Tsai, attracted widespread attention. They used LED flashing lights with specific frequencies to greatly reduce Alz. The non-invasive, easy-to-develop method of β-amyloid plaques in the brains of mice with a model of Hammer disease opens up a new direction for the treatment of Alzheimer's disease. Recently, the research team collaborated with MIT colleagues and researchers at the Beth Israel Deaconess Medical Center (BIDMC) to publish a non-invasive treatment on Cell that may be used to treat neurological diseases such as Parkinson's disease. Once they did not use "light", but use "electricity."
Deep brain stimulation (DBS) is a new method of implanting electrodes at specific targets in the brain for electrical stimulation to achieve therapeutic goals. For example, stimulation of the hypothalamic nucleus can be used to treat Parkinson's disease. However, this method requires opening the skull and implanting the electrodes, which may cause some complications and is a complex operation at risk for the patient.
Deep brain stimulation requires the implantation of electrodes in the brain
Is there any way to perform deep brain stimulation non-invasively?
MIT and BIDMC researchers have collaborated to propose a new approach that stimulates deep areas of the brain through electrodes placed on the scalp. This approach can reduce the risk and cost of deep brain stimulation and is easier for patients to use. In addition, in addition to Parkinson's disease, doctors also use deep brain stimulation to treat some brain diseases such as obsessive-compulsive disorder, epilepsy and depression. Researchers say the new non-invasive method can make deep brain stimulation more suitable for treating other diseases.
Deep brain stimulation For the treatment of Parkinson's disease, the electrodes are usually placed in the hypothalamic nucleus deep in the brain, a lens structure located beneath the thalamus. For many people with Parkinson's disease, delivering electrical impulses to the brain can improve symptoms, but surgery with implanted electrodes can lead to risks such as cerebral hemorrhage and infection.
Some researchers have attempted to stimulate the brain non-invasively using techniques such as transcranial magnetic stimulation (TMS, which is approved by the FDA for the treatment of depression). Because TMS is non-invasive, it is also used in normal human subjects to study the underlying science of cognition, emotion, sensation, and exercise. However, the use of TMS to stimulate deep brain structures may also result in intense stimulation of the surface area and adjustment of multiple brain networks.
High-frequency currents with slightly different frequencies at the two sides cancel each other deep in the brain, producing a low-frequency current. Source: Cell
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