New research reveals the pathogenesis of neurodegenerative diseases
February 18, 2019 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];In a recent study, scientists at the University of Virginia School of Medicine have identified potential causes of mysterious death of specific brain cells in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases.
New research suggests that cells may die due to genetic variations naturally occurring in brain cells, and until recently these genetic variants were considered identical. This change is called a "somatic chimera," which explains why neurons in the temporal lobe are the first dead neurons in Alzheimer's disease, and why dopaminergic neurons are in Parkinson's disease. The first dead neuron.
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In this study, the authors and others first discovered unexpected changes in the genetic makeup of individual brain cells. This finding may not only help explain schizophrenia, but also depression, bipolar disorder, autism and other diseases.
Further, the authors found that this mutation accumulates over time. Based on this finding, McConnell believes that neurons with significant genetic variation (called CNV neurons) may be the easiest to die. This can explain the specific death of specific neurons in different neurodegenerative diseases. For example, people with the highest number of CNV neurons in temporal lobe may develop Alzheimer's disease.
McConnell said that more work is needed to fully understand what is going on. So far, he has only studied neurons in the frontal cortex of the brain, and his research is limited by the fact that neurons can only be examined after death, so it is difficult to make direct comparisons. But he is happy to expand his research.
Information source: Brain discovery explains a great mystery of Alzheimer's, Parkinson's
Original source: William D. Chronister et al. Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex. Cell Reports, 2019; 26 (4): 825 DOI: 10.1016/j.celrep.2018.12.107
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