[Global Network Report] According to "Nikkei Business News" reported on April 19, the Japanese Institute of Physical Chemistry (referred to as the Institute of Science and Technology) and other April 14 released the use of reserves of other iPS cells cultured retinal cells, and transplanted to the eye problems The clinical study of patients has passed. A total of 5 people were transplanted, confirming that the situation was good and safe in the past year. The patient's vision loss is suppressed. This is a method of using other people's iPS cells that is favored in practical use, and safety and partial effectiveness are confirmed. Gao Xuezheng, the leader of the project of the Institute of Science and Technology, said that “the practicality has reached 70%â€.
iPS cells can grow into a variety of cells and are considered the ace of regenerative medicine. In Japan, it has begun to move toward clinical applications in areas such as Parkinson's disease, spinal cord injury, heart and corneal diseases that are difficult to treat. Riken and other advanced eye diseases that promote the clinical study of human transplantation for the first time are "senile macular degeneration". Like Parkinson's disease, which has started clinical trials, Japan is leading research in this area. Expectations that Japan will lead the world in the clinical application of iPS cells are emerging.
In 2014, Riken et al. implemented the world's first transplant surgery as a clinical study for patients with age-related macular degeneration who may cause blindness. At that time, iPS cells cultured in the patient's own cells were utilized. On the other hand, if you use the iPS cells of others who have confirmed safety in advance, the cost per person can be greatly reduced. The reserve cells also have the advantage of being able to be used immediately when necessary.
The clinical study was conducted in collaboration with patients from the same disease, including the Ryokan, the Kobe City Medical Center Central Citizen Hospital, the Kobe City Kobe Eye Center Hospital, Osaka University, and Kyoto University. After March 2017, patients were gradually transplanted with retinal cells cultured from other iPS cells of Kyoto University.
After 1 year, the transplanted cells of 5 people were stabilized, and it was confirmed that the structure of the damaged eye was repaired. iPS cells utilize a special type of rejection that is less prone to rejection, but one patient has mild symptoms. Takahashi said that the successful suppression of symptoms through the use of steroid drugs "is in line with the expected results."
Symptoms of retinal edema occurred in the complication, and one patient was admitted to hospital, but this was not clinically serious. The patient's vision was basically maintained and one person's vision improved. However, the patient is still using the drug continuously, and it is difficult to judge whether it is the effect of the transplant. The research team commented that it is effective in preventing vision deterioration. In the future, we plan to explore which types of patients have higher therapeutic effects through new clinical studies.
There are about 700,000 patients with age-related macular degeneration in Japan. Although drugs that prevent abnormal blood vessel growth are used, they do not work for some people. This disease is one of the diseases that are difficult to cure. (Reporter Wang Huan)
Source: World Wide Web
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