Brand is not the only, cost-effective fluorescence quantitative PCR instrument purchase guide!

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Since 1996 ABI company launched the world's first quantitative PCR since, after 10 years of development, due to the widespread application of quantitative PCR instrument in scientific research, testing and diagnostics, the market scale has been expanding. A number of domestic and foreign manufacturers have been involved in research and development , and even Eppendorf has launched its own fluorescence quantitative PCR instrument at the end of 2006 . These products are mixed, which makes it difficult for researchers to choose. So many well-funded laboratories have chosen to buy several of the most famous companies for insurance, such as ABI 's 7500 and 7900 , Roche's Lightcycler 2.0 , Lightcycler 480 , Eppendorf mastercycler and other products. However, these brand-name products are high in price because of the brand premium, and many other laboratories that are not well funded are discouraged. The performance of these products has been compared in a large number of articles, and will not be described too much here. But the brand is not the only one, and the researcher should not be superstitious about the brand. The choice made by relying on his own real experience is the most accurate. The following comprehensive research experience of a large number of scientific researchers focuses on introducing a number of fluorescent quantitative PCR instruments that are currently cost-effective on the market .


Import articles


1.Bio-rad

Bole is a mid-end brand in the world. In China, the electrophoresis system was first known to the majority of scientific users. Böhler 's PCR product line is also relatively rich, and it has further enriched the PCR product line after the acquisition of MJ Rearch . At present, Bole's IQ5 real-time PCR instrument is a cost-effective product, using 96- well Peltier semiconductor heating, 5- channel, 12-bit CCD detection, and also with gradient function. The price is also much lower than the ABI7500 , so there have been more users in the past two years. However, some users have said that the detection sensitivity of this instrument is not very good, and the maintenance rate is relatively high. The actual situation can also be further understood by consulting old users.


2.BIONEER

Domestic users may have heard of this brand. Only the laboratories and research institutes or scholars who use imported primers in the early days know the brand. Bioneer was originally started with high-throughput primers, and primer synthesis is highly recognized internationally. After 10 years of development, the product line has covered the entire molecular biology field, and is currently almost identical to the product line of takara . The price of BIONEER 's ordinary gradient PCR instrument is very lethal compared to the price of other imported equipment. The company also introduced the ExicyclerTM 96 , a fluorescence quantitative PCR instrument at the end of 2006. The technical parameters of the product are also 96- well Peltier semiconductor heating, 5- channel, 16-bit CCD detection, and gradient function . The parameters of this product are almost the same as those of Bio-rad 's IQ5 , and the detected CCD pixels are higher than IQ5. In theory, the detection sensitivity should be better. The product price is said to be lower than Bio-rad , and it is said to be the most cost-effective PCR instrument. But the downside is that there are very few domestic users, and it is not easy to understand. Interested customers can contact Beijing Litu Technology Co., Ltd. for trial use. The new company pays attention to after-sales service. After all, you have to be personally aware that it is the most reliable.

3.Stratagene
Stratagene is now a subsidiary of Agilent and a company specializing in molecular biology research product development. In China, its reagent products are not sold much, and it is in the promotion stage. Stratagene 's fluorescent quantitative PCR product Mx3005P has the same technical parameters as the above two products. It is similar to 96- well Peltier semiconductor heating, 5- channel, PMT detector, but without gradient function, users can not optimize the reaction conditions on this instrument. In addition, some customers have responded that the instrument is rough and the noise is relatively large, and the effect of the edge of the hole is not very good, but it is good to use the hole in the middle of the thermal module. This kind of problem also exists on the ABI7500 instrument, but the price of Stratagene is much more affordable.

Domestic articles
At present, the domestic life science research market is basically monopolized by foreign multinational companies. Domestic manufacturers can only occupy a small part of the market by the bottom price. In all fairness, domestic manufacturers have a certain gap with foreign manufacturers in terms of technology and technology. However, this is also due to the objective reasons of China's basic research level and the relatively late start of manufacturing process. Coupled with the problems of domestic manufacturers' operations and financial resources, the staff treatment that can be provided has a certain gap with multinational companies. The talents attracted are also limited. The CEOs of domestic production equipment companies have bluntly stated that they have not yet been able to invite world-class designers and the ability to improve production processes. They can only rely on low prices to occupy a part of the market until the original accumulation reaches a certain level. Products strive to enter a higher level of the market. Of course, we also see that domestic manufacturers are also making continuous progress. As more and more top talents join the field of biotechnology, it is believed that the biotechnology market will slowly adopt foreign manufacturers like the home appliance market of the year. The monopoly situation broke and regained most of the market. Here are a few of the quantitative PCR machines produced by domestic manufacturers .

1. Hangzhou Bo Day

When it comes to domestic PCR machines, I have to mention Hangzhou Bori Company, which, like Takara , is a biotechnology company that invested in Japan earlier in China. Bozhi Company once occupied a large market in the field of low-end PCR instruments. Although in recent years, with the impact of other domestic brands, the market share has been seriously reduced, but overall it is still at the leading level. The company's fluorescence quantitative PCR product FQD -48A It is a 4- channel, 48- well Peltier semiconductor heater. Compared with several imported products introduced above, the sample throughput and detection optical path are lower, but it can also satisfy the users whose experimental samples are not very large. Moreover, the price of the Bo Ri products is lower than the prices of several imported products introduced earlier.
2. Xi'an Tianlong

Xi'an Tianlong's fluorescent quantitative PCR product TL988 is a truly multi-channel real-time PCR instrument developed by the domestic independent research , TL988 design is more flexible, optional 36- hole and 96- well heating module, but the channel and multi-channel combination mode. Up to 5 channels, but the disadvantage is that the single-excitation filter is still used, and the excitation light specificity is not good, resulting in low detection sensitivity. It is understood that the medical system in China is still some users, and there are fewer users of scientific research systems.
3. Shanghai Hongshi

SLAN® real-time PCR, produced by Shanghai Hongshi, is a good instrument in the domestic market . It is the most recognized instrument for detection sensitivity and repeatability in the performance comparison of domestic quantitative PCR machines. The downside is that the number of optical paths and sample holes is relatively small. Models with a maximum of three channels and 48 sample wells do not meet the needs of larger sample sizes. At present, in the hospital clinical laboratory, it is the highest-selling instrument of domestic fluorescence quantitative PCR instrument, and there are few users in scientific research system.

Section: At present, most of the market share is still occupied by foreign manufacturers, especially in research , CDC and blood stations, and foreign manufacturers are in a monopoly position. However, domestic manufacturers currently have a place in the hospital clinical inspection system. Researchers and medical workers still have to make choices based on their actual needs and personal experience . The famous saying " choose the right, not expensive " is also applicable to the purchase of a real-time PCR instrument.

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