The fully sealed centrifuge adopts the traditional mechanical seal. The advantage of the mechanical seal is that the structure is simple, the technology is mature, and the processing precision is not high. The disadvantage is that the service life is short, the power consumption is large, and the liquid medium must be lubricated and cooled on the sealing surface. Fluctuations in the parameters of the production process have a great impact on the seal. So the little knowledge about the centrifuge seal processing is not known, the following is introduced by the small editor of Hunan Gilson.
1. Introduction of the sealing position of the centrifuge bearing: The sealing of the spindle nut and the bearing position of the centrifuge. The sealing measures of the previous conventional models in this respect are relatively simple and can only be relatively sealed. For example, the spindle nut part, the spindle nut and the drum joint surface, generally no sealing ring is provided. The liquid phase and the gas phase infiltrate during the operation of the centrifuge, causing corrosion to the taper surface of the spindle, and even infiltrating into the bearing, causing damage to the bearing, thereby affecting The normal use of the machine. The upper bearing cap is generally provided with a skeleton seal and the like, but a part between the upper bearing cap and the drum cone is exposed, and the gas phase in the inner cavity of the centrifuge may corrode the exposed surface of the spindle. The centrifuges used in the pharmaceutical industry mostly contain organic solvents or acids, alkalis, salts and other media. Therefore, when ordering equipment, the sealing requirements of these parts should be fully taken into account, and dynamic sealing or static sealing structures should be provided to achieve Sealing requirements.
2. Introduction of the sealing of the working belt of the centrifuge belt: The transmission belt of the traditional centrifuge is open, but a protective cover is arranged at the motor end, mainly from the safety point of view, to improve the safety of its use, but for the friction The pollution of dust to the environment is not controlled. For example, it is not feasible to use it in the clean area. Therefore, the working area of ​​the belt must be sealed to prevent the leakage of friction dust.
3. Introduction of centrifuge cover: Since the cover of the centrifuge can be turned over, the joint surface of the centrifuge should have reliable sealing measures. If the seal structure or material fails to prevent corrosion, it may cause leakage of liquid and gas. The environment and personnel cause harm. The anti-corrosion performance of the sealing groove structure and the sealing strip should be fully considered in the design and selection of its sealing performance and reliability. For the installation interface of the feeding device, washing tube, sight glass and other additional devices, there should also be reliable sealing measures.
This article was edited by the laboratory instrument - Hunan Gilson Technology Development Co., Ltd.
Intermediate – Intermediate: A material produced during a drug substance processing step that must undergo further molecular modification or refinement to become a drug substance. Intermediates may or may not be isolated. Intermediates are the key products of the previous process of making APIs, which are different in structure from APIs.
for example:
Amoxicillin capsules are called preparations, amoxicillin is called API, and 6-APA is called intermediate.
Ceftriaxone sodium powder is called preparation, sterile ceftriaxone sodium is called API, and 7-ACA is called intermediate.
Our company specializes in providing key intermediates for various APIs
Intermediate is a very important type of fine chemical products. Its essence is a type of "semi-finished product", which is an intermediate product in the production of certain products. For example, if a product is to be produced, it can be produced from intermediates, saving costs and reducing It is widely used in the synthesis of medicines, pesticides, coatings, dyes and spices. In the field of medicine, intermediates are an important link in the industrial chain of the pharmaceutical industry. They are used for some chemical raw materials or chemical products in the process of drug synthesis. In a word, they are used to produce APIs.
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