Arsenic trioxide, commonly known as "Aromatic Cream" (ATO), has been considered the "king of poison" since ancient times. However, in the molecular science and biomedical laboratory of Hunan University, arsenic has been incubated with folic acid and human serum albumin, which seems to have been trained as a "eye of the eye", which can be targeted to cancer cells, and "poison" can also become chronic leukemia. The "good prescription" for treatment. Recently, the results were published in the international top chemical journal "German Applied Chemistry".
In the medical world, arsenic can treat acute promyelocytic leukemia (APL) long ago. The arsenic in arsenic has an induced differentiation effect on acute promyelocytes and causes apoptosis of cancer cells. With the use of arsenic, the “five-year disease-free survival rate†of APL patients jumped from about 25% to about 95%. As a result, arsenic has become one of the world's standard drugs for the treatment of APL, which is another award-winning contribution of traditional Chinese medicine to patients around the world.
However, for patients with chronic myeloid leukemia (CML), arsenic is a craving and a terrible prescription. Unlike arsenic, which is targeted to cancer cells in APL treatment, arsenic is not effectively enriched in cancer cells in CML treatment, and high-dose treatment regimens are prone to nerve damage and liver failure. Serious side effects. The development of arsenic for the treatment of other malignant leukemias and solid tumors such as CML is a long-cherished wish of the majority of scientists.
In response to this problem, the National Key Laboratory of Chemical Biosensing and Metrology, the College of Chemistry and Chemical Engineering and the College of Biology of Hunan University jointly established the "Molecular Science and Biomedical Laboratory (MBL) Academician Tan Weijun's research group" with the help of arsenic and albumin. The internal thiol reversible binding chemistry, the use of a non-toxic reducing agent to open the disulfide bond of folate-linked human serum albumin (FA-HSA), and then incubated with arsenic, developed folate receptor targeting Albumin arsenic nano drug (FA-HSA-ATO).
"Albumin itself has a certain role in targeting cancer cells, and surface-modified folic acid can further effectively target cancer cells and enhance the enrichment of arsenic in tumor cells. They are equivalent to adding double eyes to arsenic, which can be more precise. Find cancer cells, place arsenic, kill cancer cells, reduce the enrichment of arsenic in normal organ tissues, and thus reduce the side effects of arsenic while effectively treating CML," research team member Peng Yubo, associate researcher told reporters. At the same time, the albumin arsenic nano drug has the advantages of simple preparation and good biocompatibility.
The team is currently conducting further research to develop relevant clinically applied treatment options.
Source: People's Network
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