Release date: 2018-01-15
Because the fatality rate is as high as 88%, the Marburg virus can completely destroy a community within a few days; in 2005, the Marburg virus broke out in a paediatric ward in Angola, eventually causing 374 infections, of which 329 were fatal due to There is currently no effective treatment for Marburg virus infection, so researchers urgently need to develop effective treatments for the virus.
Recently, a research report published in the international magazine Cell Host & Microbe, researchers from the Scripps Research Institute developed the first new treatment for the treatment of Marburg virus infection, the pathogen with Ebo Pulling the virus has potential pandemic capabilities and threats; previous studies have found that an antibody called MR191 can effectively neutralize the Marburg virus, but no one knows that at least this antibody drug targets the Marburg virus. Molecular mechanism.
In this study, the researchers mapped out the structure of the Marburg virus. Based on high-resolution imaging techniques, the researchers revealed how MR191 targets and neutralizes the Marburg virus. This antibody treatment strategy may provide researchers with The foundation helps develop effective therapies for the treatment of Marburg virus infection. Researcher Dr. Erica Ollmann Saphire said that this is the first antibody we have discovered to treat Marburg virus infection. Based on the analysis of the structure of the virus, we can observe the molecular mechanism by which the antibody works. Now we have studied a lot of viruses. Details, which are essential for later development of new treatments or vaccines to prevent viral infections.
Using X-ray crystallography, the researchers found that MR191 can effectively neutralize Marburg virus by mimicking the host receptor and inserting it into the receptor binding site on the surface of the virus, since the receptor binding site on the surface of the virus is already occupied. The virus can no longer absorb human cells and spread infection. The researchers' imaging results revealed a portion of the "wing" structure that stretched out on one side of the viral structure, which is important for researchers to study in depth because it is one of two known sites that protect human antibody binding.
As researchers began to develop plans to fight the Marburg virus infection, they also began to notice how the Marburg virus took some strategies to show the difference with its close relative, the Ebola virus. This latest study shows that it is not like Ebo. Pulling the "wing" structure of the virus, the "wing" structure of the Marburg virus can be folded around the outside of the glycoprotein protrusion. Researcher Ollmann Saphire said that this structural study tells us that the Marburg virus seems to be structurally different from Ebola, which means that the treatment of one of the viral infections seems to be different from the other. the same.
Another key difference is that when both viruses use a glycan "hat" to protect the receptor site that is susceptible to the human immune system, this study shows that MR191 can bypass the corncob glycan "hat" "The researchers did not observe this ability in any antibodies that previously resisted Ebola virus infection." Researcher Ollmann Saphire said that next step they will plan to study how known mutations in Marburg virus can evade the targeted binding of antibodies and how to use current research information to design novel therapies; of course, researchers also hope that antibody therapy can enter In clinical trials, researchers have now licensed MR191 to business partners for in-depth development research.
Source: Bio Valley
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